Sodium Hyaluronate
Sodium hyaluronate has a lower molecular weight than HA and hydrolyzed HA, so it’s more easily absorbed into pores. “Sodium hyaluronate has the ability to penetrate into deeper layers of the skin, and also attracts and binds water,” the cosmetic chemist says. “This effect can plump the skin, thus reducing the look of wrinkles and making skin younger-looking.
“This form is less susceptible to oxidation, so it's more stable,” Dr. Geria adds. That stability makes sodium hyaluronate attractive to product formulators. In fact, the dermatologist notes that “almost all ‘hyaluronic acid’ serums will actually contain sodium hyaluronate as the key active ingredient.” The terms are used interchangeably, so while your faves — SkinCeuticals HA Intensifier, The Ordinary Hyaluronic Acid 2% + B5 — may say “hyaluronic acid” on the front of the bottle, the back of the bottle lists “sodium hyaluronate.”
The risks of hydrolyzed HA and sodium hyaluronate are pretty minimal, but there’s evidence to suggest you can have too much of a good thing. “It needs moisture to work, so when applied to skin in dry conditions where humidity is low, it will pull moisture from wherever it can; that’s just the nature of the beast,” The Cut reported. “If there’s no humidity to be obtained from the air, it draws moisture from the deeper layers of skin and brings it to the surface of the epidermis, whence it evaporates, leaving skin drier than it was.” The solution here is twofold: Use only one HA-containing product at a time, and seal it in with a moisturizer or oil.
As with any ingredient, “irritant or allergic reactions are always possible,” Dr. Geria says. Some beauty enthusiasts find they have sensitivities to sodium hyaluronate, but their skin thrives on hydrolyzed HA (it’s a big topic of conversation in Reddit’s Skincare Addiction community). One study theorizes this is because the low molecular size of sodium hyaluronate can cause inflammation. If you notice any inflammatory symptoms — blemishes, redness, irritation — you may want to hold off on the sodium hyaluronate serums and moisturizers to see if that helps.
Hyaluronic acid has two salt forms: sodium hyaluronate and potassium hyaluronate. As the name suggests, sodium hyaluronate is the sodium salt version.
Sodium hyaluronate is part of HA. It can be extracted and used separately. This is important because it changes how the substance affects the skin. The difference comes down to molecular weight. Hyaluronic acid has a high molecular weight, which means it’s a macromolecule. The large molecules coat the skin and prevent water loss, leading to better hydration.
Sodium hyaluronate has a low molecular weight. It’s small enough to penetrate the epidermis, or top layer of the skin. In turn, it can improve hydration from the underlying skin layers.
Since sodium hyaluronate is derived from HA, it’s sometimes called “hyaluronic acid.” It may be listed as “hyaluronic acid (as sodium hyaluronate)” on skin care labels.